The Epigenetics and Gene Dynamics Initiative brings together investigators from across the HMS campus. Members of our Steering Committee represent the diverse interests and expertise of the HMS departments and affiliated hospitals.
Karen Adelman, Dept. of Biological Chemistry and Molecular Pharmacology, HMS
The Adelman lab studies how cells react in a rapid, yet balanced manner to external signals, at the transcriptional and epigenetic level. We use a combination of genomics, genetics and biochemistry to study the dynamics of gene expression, with a focus on developmental systems.
Fred Winston, Department of Genetics, BBS, HMS
The Winston laboratory focuses on understanding eukaryotic gene expression and chromatin structure, using the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe.
Shirley Liu, Department of Data Science, Dana Farber Cancer Institute and Harvard University
The research in Shirley Liu Lab focuses on algorithm development and integrative modeling of high throughput genomic data to understand the specificity and function of regulator genes in tumor development, progression, drug response and resistance. Liu Lab is especially interested in genomics and bioinformatics approaches in cancer epigenetics, cancer immunology, and CRISPR screens for translational cancer research.
Danesh Moazed, Department of Cell Biology, Howard Hughes Medical Insitute
The Moazed lab is interested in understanding how genes are silenced and how gene silencing is epigenetically inherited during cell division and across generations. His group uses a broad range of approaches ranging from genetics and biochemistry to structural biology to study this problem in yeast and mammalian cells.
Yang Shi, Cell Biology Department, Harvard Medical School, Division of Newborn Medicine, Boston Children’s Hospital
The Shi lab discovers and studies enzymatic machineries that regulate covalent histone and RNA modifications and their link to human diseases including cancer and neurological disorders.
Robert Kingston, Department of Molecular Biology, Harvard Medical School, Massachusetts General Hospital
The Kingston lab is interested in understanding the fundamental mechanisms of how eukaryotic enzymes can modify chromatin. One focused approach is to isolate chromatin-modifying proteins and to test such complexes in functional assays, with the thesis that assay outcomes will inform the in vivo function of these protein machines. Another important goal is to understand how long-range chromatin interactions are established in the cell nucleus, and this effort is leading to new strategies toward defining such interactions in vivo.
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