HMS Epigenetics & Gene Dynamics Annual Symposium

HMS Epigenetics & Gene Dynamics Annual SymposiumSympoisum Poster Session
September 26, 2019, 8AM - 5PM
Merck Research Building

33 Avenue Louis Pasteur, Boston


Barbara Meyer
HHMI Investigator
Professor of Genetics, Genomics, and Development
Department of Molecular and Cell Biology
University of California, Berkeley

Learn more about Barbara Meyer

Since 2014, HMS has organized an annual Epigenetics symposium as an opportunity for researchers in the community to share their recent progress. These highly-interactive symposia draw > 300 people, and feature talks from across HMS, including recipients of our seed grants. A poster session is open to all, and lunch and refreshments are served throughout the day.

If you have registered for the symposium and you wish to speak at the retreat, please submit an abstract by emailing Vonda Shannon


Download Schedule Here





8:45 - 9:00AM 

Welcome, Introductions, and Announcements of 2020 Grants 

Co-Organizers: Karen Adelman, Fred Winston, Yang Shi, Danesh Moazed, Shirley Liu and Bob Kingston

9:00 - 10:45 AM 

Session 1 

 Yang Shi, BCH, HMS Cell Bio, Chair

9:00 - 9:20AM Speaker: Scott Armstrong*, BCH Targeting Chromatin to Reverse Leukemia Stem Cell Gene Expression
9:20 - 9:40AM Speaker: Bill Hahn*, BCH Curating an atlas of human gene function from CRISPR-Cas9 fitness screens
9:40 - 10:00AM Speaker: Elizabeth Jaensch, GS, Kingston Lab Adding Compaction and Phase Separation Activity to Cbx7 Impacts ES Cell Differentiation
10:00 - 10:25AM Speaker: Len Zon, HHMI, BCH, HSCI Using transcription to change cell fate in stem cells and cancer
10:25 - 10:45AM Speaker: Marty Yang, GS, Greenberg Lab Elucidating Determinants of Enhancer Function with Natural Genetic Variation

10:45 - 11:05AM 

Coffee Break 


11:05 -12:30PM 

Session 2 

Shirley Liu, DFCI, Chair  

11:05 - 11:30AM Speaker: Galit Lahav, HMS, Systems Bio The Impact of Protein Dynamics on Radiation Sensitivity
11:30 - 11:50AM Speaker: Kent Mouw*, DFCI, BWH The Role of the Histone Lysine Demethylase KDM6A in Bladder Cancer Tumorigenesis and Therapy Response
11:50 - 12:10PM Speaker: Rani George, DFCI The CTCF Paralog, BORIS, Promotes Novel Chromatin-Based Regulatory Interactions in Treatment- Resistant Cancer Cells
12:10 - 12:30PM Speaker: David Sinclair, HMS Genetics Reversing the age of neurons in vivo to improve retinal survival and function

12:30 - 1:40PM 

Lunch & Coffee 


1:40 – 3:40 PM

Session 3

  Danesh Moazed, HMS Cell Bio, Chair

1:40 – 1:50 PM

Karen Adelman and Fred Winston

Grant Process and Review

1:50 - 2:15PM Speaker: Connie Cepko, HMS Genetics Finding and validating cis-regulatory modules: lessons from the retina
2:15 - 2:35PM Speaker: Sarah Morton*, BCH, HMS Cell Bio Epigenetic Prioritization of Non-Coding Variants in Congenital Heart Disease
2:35 - 2:55PM Speaker: Simon Yuan, PD, Greer Lab The Role of Epigenetics in the Transition from Unicellularity to multicellularity in Dictyostelium Discoideum
2:55 - 3:15PM Speaker: Brendan Price*, DFCI Histone H3.3 mutations reprogram the DNA repair machinery of pediatric gliomas
3:15 - 3:40 Speaker: Richard Gregory, BCH, HSCI, HMS BCMP Role of the RNA epitranscriptome in gene regulation and cancer

3:40 - 4:00PM

Coffee Break


4:00 – 5:00PM 

Keynote Address: 

Barbara Meyer, HHMI Investigator, Dept. of Molecular and Cell Biology, UC Berkeley

Remodeling and Repressing X Chromosomes via Molecular Machines

Bob Kingston, MGH, Chair

5:00- 6:00PM 

Poster Presentation, Voting, and Reception